Define the transfer purpose
Determine whether the operation is a single transfer, continuous supply, or recirculation.
Biopharma · APPLICATION GUIDE
Pumps & Fluid Transfer
Compare product damage, pulsation, residual volume, and cleaning conditions as well as flow rate and pressure.
Review selection pointsDiscuss this applicationFIELD APPLICATION & FLOW
See the application in its industrial setting.
Review product locations and fluid paths.
APPLICATION IN CONTEXT
- Supply bag
- Tubing pump
- Flow/pressure check
- Receiving bag
- Process record
Connections to review
- 01 → 02 Supply bag → Tubing pump
- 02 → 03 Tubing pump → Flow/pressure check
- 03 → 04 Flow/pressure check → Receiving bag
- 03 → 05 Flow/pressure check → Process record
Evaluate pump tubing, connections and actual-fluid quality and recovery together.
A conceptual illustration created to explain equipment and application locations. It is not an actual product photograph, installation photograph or piping/wiring design.
Connection principles and operating/test methods
Check transfer flow and pressure together
Fluid
Scroll horizontally to see the complete flow.
Select pump type according to viscosity, shear, bubbles, flow, and pressure. The diagram does not indicate the performance of a particular pump or suitability for every fluid.
These conceptual views explain flow direction. Actual piping, wiring and physical flow rates require a separate design.
01 — PROCESS
Where does each step fit?
Define the intended use and conditions to identify the required role of each item.
Compare pumps and piping
Check minimum/maximum flow rates, system pressure losses, and the control range.
Test the product and process
Use the actual liquid to evaluate recovery, quality, flow stability, and operating time.
02 — SELECTION
What should be selected and verified?
Media supply, harvest fluid transfer, TFF recirculation, and transfer before filling have different requirements. Evaluate each pump type using the actual liquid and piping, and review material, sterilization, and traceability documentation for wetted components.
Scroll horizontally to review all columns.
| Process objective | Step to review | Selection evidence |
|---|---|---|
| TFF recirculation | Recirculation flow and pressure control | Integration with TMP control, shear, temperature rise, and extended operation |
| Sensitive product transfer | Product quality | Cell viability, protein aggregation, vector activity, and bubbles |
| Precision supply | Flow stability | Pulsation, reproducibility at low flow, and sensor and control integration |
| Wetted component management | Reusable / replacement components | CIP/SIP or sterilization compatibility, E&L, and residual volume |
Compare actual operating conditions with supplier evidence and confirm the required performance and validation scope.
03 — OPERATING CHECKS
Use operating data to identify improvements.
Review the pump curve together with the system
The operating point changes with tubing length and internal diameter, and differential pressure across valves and filters.
Test the effects on the product
Do not judge by descriptions such as low shear alone. Check quality changes at the actual number of recirculation passes and operating time.
Compare operating costs
Include tubing and head replacement, cleaning, installation space, maintenance, and control integration.
04 — QUESTIONS
Frequently asked questions
Which is best: a magnetically levitated, centrifugal, or peristaltic pump?
The choice depends on the required flow rate and head, product sensitivity, pulsation, and the approach to managing wetted components. Narrow the candidates for each type using the process conditions.
Can a pump be selected using only its rated maximum flow?
Confirm that it can deliver the required flow under the piping pressure losses and actual viscosity. Stable control at the minimum flow is also important.
05 — APPLICATION REVIEW
Prepare the conditions for a technical discussion.
These details help narrow the configuration and the evidence to review.
- Fluid, viscosity, and sensitivity
- Minimum/maximum flow rate and required head
- Piping internal diameter, length, and downstream equipment
- Sterilization/cleaning method and operating time
- Allowable pulsation and product quality criteria